High Power-High Dose-Pulsed Laser Therapy on Stem Cells

Published by diowavelaser on

High Power-High Dose-Pulsed Laser Therapy on Stem Cells

Photobiomodulation and Stem Cell Activation

A review of pertinent medical literature shows how laser therapy treatments can safely and effectively activate stem cells. There is no detrimental effect whatsoever upon the stem cells. Laser therapy causes stem cell activation at the target site of photonic stimulation. Stem cell proliferation has been shown to occur along with the maintenance of cellular viability.

Laser therapy also enhances stem cell injections by accelerating articular cartilage regeneration, pain reduction and reduction of boney edema just to name a few of the numerous synergies between the two procedures. Laser enhances stem cell outcomes, it never detracts.

Laser therapy adds a cost-effective long-term maintenance program for stem cell patients. It can also act as a stand-alone modality to treat pathologies for those patients that cannot afford stem therapy or for those who did not have a positive outcomes.

How to Integrate Diowave Laser Systems into your Medical Practice

A. Laser as a Stand-alone Modality: As an alternative treatment option to stem cell therapy, laser therapy treatment costs are less expensive to the patient, can be administered by a medical assistant and might even provide better clinical outcomes.

B. Administering Laser Therapy Treatment Post Stem Cell Therapy: Integrating laser therapy treatment with stem cell treatment will enhance tissue regeneration at the onset.

C. Administering Laser Therapy Treatment Post Stem Cell Therapy for Longer Term Maintenance: Laser therapy treatments are an effective long-term maintenance therapy post stem cells therapy. The cost to the patient is minimal compared to having to repeat stem cell injections.


Below is a list of pertinent list of medical literature support the use of laser therapy and stem cell research.

  1. Lasers Med Sci. 2018 Jan;33(1):95-102. doi: 10.1007/s10103-017-2355-y. Epub 2017 Oct 12. Lowlevel laser irradiation induces in vitro proliferation of stem cells from human exfoliateddeciduous teeth.
  2. Ginani F1, Soares DM2, de Oliveira Rocha HA3, de Souza LB1,4, Barboza CAG5,6. Stem Cell Rev. 2018 Aug;14(4):585-598. doi: 10.1007/s12015-017-9796-3. Beneficial Role of Low-Intensity Laser Irradiation on Neural β-tubulin III Protein Expression in Human Bone Marrow Multipotent Mesenchymal Stromal cells.
  3. Ferreira-Silva V1,2, Primo FL3, Baqui MMA4, Magalhães DAR2, Orellana MD2, Castilho- Fernandes A1, Cruz MC5, Câmara NOS5, Covas DT2,6. Tedesco AC7. J Interv Cardiol. 2018 Jul 12. doi: 10.1111/joic.12539. [Epub ahead of print] Adjunctive laser-stimulated stem-cells therapy to primary reperfusion in acute myocardial infarction in humans: Safety and feasibility study.
  4. Elbaz-Greener G1,2,3, Sud M3, Tzuman O1,2, Leitman M1,2, Vered Z1,2, Ben-Dov N4, Oron U5, Blatt A1,2. J Cell Physiol. 2013 Jan;228(1):172-81. doi: 10.1002/jcp.24119. Photo-activation of bone marrow mesenchymal stromal cells with diode laser: effects and mechanisms of action.
  5. Giannelli M1, Chellini F, Sassoli C, Francini F, Pini A, Squecco R, Nosi D, Bani D, Zecchi-OrlandiniS, Formigli L. IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3). pii: 7000417. doi: 10.1109/JSTQE. 2016.2561201. Proposed Mechanisms of Photo-biomodulation or Low-Level Light Therapy.
  6. de Freitas LF1, Hamblin MR2. PLoS One. 2017 Jun 8;12(6):e0179175. doi:10.1371/journal.pone.0179175. eCollection 2017. Low level laser (LLL) attenuate LPS-induced inflammatory responses in mesenchymal stem cells via the suppression of NF-κB signaling pathway in vitro.
  7. Yin K1, Zhu R1, Wang S1, Zhao RC1. J Cell Physiol. 2018 Oct;233(10):7026-7035. doi: 10.1002/jcp.26626. Epub 2018 May 10. Photo-biomodulation therapy and vitamin C on longevity of cell sheets of human dental pulp stem cells.
  8. Pedroni ACF1, Diniz IMA1,2, Abe GL1, Moreira MS3, Sipert CR1, Marques MM1. Int J Mol Med. 2018 Oct;42(4):2107-2119. doi: 10.3892/ijmm.2018.3804. Epub 2018 Aug 2. High-fluence low-power laser irradiation promotes odontogenesis and inflammation resolution in periodontitis by enhancing stem cell proliferation and differentiation.
  9. Hou T1, Li S2, Zhang G2, Li Y1. J Photochem Photobiol B. 2018 May;182:77-84. doi: 10.10.1016/j.jphotobiol.2018.03.015. Epub 2018 Mar 22. Combined effects of photo-biomodulation and alendronate on viability of osteoporotic bone marrow- derived mesenchymal stem cells.
  10. Fallahnezhad S1, Amini A1, Hajihossainlou B2, Chien S3, Dadras S4, Rezaei F5, Bayat M6. Lasers Med Sci. 2018 Sep 19. doi: 10.1007/s10103-018-2638-y. [Epub ahead of print] Effect of photobiomodulation on neural differentiation of human umbilical cord mesenchymal stem cells.


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